Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosis
Here, a murine model of iron overload-induced hepatic ferroptosis was established, and a gene signature indicative of hepatic ferroptosis response in both mice and humans was identified. These findings underscore the role of ferroptosis in liver injury progression and suggest potential therapeutic targets for liver disease intervention.
Authors
- Takashi Matsumoto (ORCID: https://orcid.org/0000-0001-6791-6441)
- Katsuya Nagaoka (ORCID: https://orcid.org/0000-0002-7152-6101)
- Noriko Yasuda‐Yoshihara (ORCID: https://orcid.org/0000-0001-9550-3257)
- Yasuhito Tanaka (ORCID: https://orcid.org/0000-0002-2473-6966)
- Hiromitsu Hayashi (ORCID: https://orcid.org/0000-0002-1832-4287)
- Yuta Matsuoka (ORCID: https://orcid.org/0000-0001-9860-3851)
- Akihiro Nita (ORCID: https://orcid.org/0000-0003-2647-5445)
- Kosuke Mima (ORCID: https://orcid.org/0000-0002-4385-4984)
- Hirohisa Okabe (ORCID: https://orcid.org/0000-0003-3041-7563)
- Ayato Maeda
- Katsunori Imai (ORCID: https://orcid.org/0000-0003-0549-1825)
- Yuki Sugiura (ORCID: https://orcid.org/0000-0002-6983-8958)
- Toshiro Moroishi (ORCID: https://orcid.org/0000-0001-6419-3882)
- Yohei Kanamori (ORCID: https://orcid.org/0009-0003-4062-5910)
- Hideo Baba (ORCID: https://orcid.org/0000-0002-3474-2550)
- Keiichi I. Nakayama (ORCID: https://orcid.org/0000-0002-7185-1529)
- Tomomi Nita
Institutions
- Kyushu University (JP)
- Kyoto University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1097/hc9.0000000000000721
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56