IgE clonality and aggregation of insulin affect IgE-mediated activation of sensitized basophils
This study illustrates why diagnostic methods for insulin allergy are difficult to correlate to clinical symptoms. Insulin aggregation and IgE clonality may be important factors in developing clinical symptoms of insulin allergy and should be addressed to improve the diagnostic outcome of insulin allergy testing.
Authors
- Henrik Toft‐Hansen
- Eva Johansson (ORCID: https://orcid.org/0000-0001-9330-5169)
- Anders Millner
- Steffen Christoffersen
- K Baumann (ORCID: https://orcid.org/0000-0002-0656-3897)
- Per Stahl Skov
- Camilla Thorlaksen
Institutions
- Novo Nordisk (Denmark) (DK)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1016/j.jacig.2025.100502
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novo Nordisk