A Modular Cyclopentene Annulation
We report a modular three-component annulation among propargyl zinc reagents, unsaturated 1,3-dicarbonyls, and electrophiles to enable rapid construction of highly substituted cyclopentenes. In addition to optimization studies, a range of substrates were investigated. These products can be readily diversified to highlight their synthetic utility.
Authors
- Adrian E. Samkian (ORCID: https://orcid.org/0000-0002-0068-3572)
- Brian M. Stoltz (ORCID: https://orcid.org/0000-0001-9837-1528)
- Kasam Poonswat
- Scott C. Virgil (ORCID: https://orcid.org/0000-0001-8586-5641)
Institutions
- California Institute of Technology (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1021/acs.orglett.5c01750
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Caltech Associates
- Heritage Medical Research Institute
- Chulabhorn Graduate Institute, Chulabhorn Royal Academy
- National Institute of General Medical Sciences