Patients Hospitalized with COVID-19 Demonstrate Distinct Plasma Cytokine and Chemokine Concentrations in vivo and TLR-Mediated Cytokine and Chemokine Production in Whole Blood in vitro
Higher plasma concentrations of IL-27, CXCL10, and ADAs at admission were associated with severe COVID-19 and mortality. Reduced TLR-mediated IFNα2, IFNγ, and IL-12p70 production suggests COVID dampens Th1-polarizing innate immune responses, providing insight into immunological sequelae of SARS-CoV-2 infection.
Authors
- Joann Diray‐Arce (ORCID: https://orcid.org/0000-0003-2183-4269)
- Alec L. Plotkin (ORCID: https://orcid.org/0000-0003-3831-9845)
- Simon Doss-Gollin (ORCID: https://orcid.org/0000-0001-8797-7452)
- Kerry McEnaney (ORCID: https://orcid.org/0000-0002-0378-3456)
- Oludare A. Odumade (ORCID: https://orcid.org/0000-0002-8630-8510)
- Sanya Thomas (ORCID: https://orcid.org/0000-0003-3648-9461)
- Simon D. van Haren (ORCID: https://orcid.org/0000-0002-1791-0161)
- Kinga K. Smolen (ORCID: https://orcid.org/0000-0001-8650-3693)
- Ofer Levy (ORCID: https://orcid.org/0000-0002-5859-1945)
- Athena N. Nguyen (ORCID: https://orcid.org/0000-0001-6779-1159)
- Al Ozonoff (ORCID: https://orcid.org/0000-0003-4233-5899)
- Lindsey Robert Baden (ORCID: https://orcid.org/0009-0004-1752-1926)
- Kevin Ryff (ORCID: https://orcid.org/0009-0000-3112-0687)
- Thomas S Kouyate
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1159/000545432
- Citations
- 2
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Institutes of Health