Genetic polymorphisms as a predisposition to metabolic syndrome: an integrative review

Metabolic syndrome is characterized by a set of metabolic disorders, including abdominal obesity, insulin resistance, dyslipidemia, and hypertension, increasing the risk of cardiovascular diseases and diabetes. Objective: This study aimed to To identify genetic polymorphisms associated with metabolic syndrome and analyze their clinical implications. Methodology: This study was an integrative review conducted an integrative review based on articles published between 2020 and 2024, utilizing the Virtual Health Library and the PubMed database. A total of 19 studies were selected according to eligibility criteria. Results: The findings highlight polymorphisms that influence metabolic risk factors, demonstrating a complex interaction between genetics and lifestyle. Conclusion: Identifying relevant polymorphisms can enhance diagnostic and preventive strategies for metabolic syndrome, particularly in primary care.