High-Fat Diet-Induced Gut Microbiota Disruption Promotes Colorectal Cancer Lymphatic Metastasis via Propionate/GPR41 Signaling
This study reveals that HFD promotes CRC lymphangiogenesis and LN metastasis through gut microbiota dysbiosis and suppression of the propionate-activated GPR41 signaling pathway. These findings highlight the therapeutic potential of targeting the propionate/GPR41 axis, offering a promising strategy for developing novel anticancer therapies.
Authors
- Min Ni (ORCID: https://orcid.org/0000-0002-6713-2812)
- Qingying Tan (ORCID: https://orcid.org/0000-0003-4536-4273)
- Junlong Yang
- Sen Zhang (ORCID: https://orcid.org/0000-0002-7783-3268)
- Xiaoli Zhang (ORCID: https://orcid.org/0000-0002-0770-5594)
- Fangfang Chen (ORCID: https://orcid.org/0000-0002-0854-1667)
- Guoliang Wang (ORCID: https://orcid.org/0000-0002-9191-6166)
- Jialei Wang (ORCID: https://orcid.org/0000-0001-9977-2219)
- Xiaoyong Zhao (ORCID: https://orcid.org/0000-0003-3492-1337)
Institutions
- Jinan University (CN)
- Guangxi Medical University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Liwan District Traditional Chinese Medicine Hospital (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Guangzhou Development Zone Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Guangdong Provincial People's Hospital (CN)
- Tumor Hospital of Guangxi Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Digestion
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1159/000545843
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05