Potential of SPHK1 as a prognostic marker and therapeutic target in colorectal cancer: insights from bioinformatics and experimental analysis
SPHK1 plays a key role in facilitating the epithelial-to-mesenchymal transition of CRC cells, enhancing their migratory and invasive abilities, and influencing the tumor microenvironment. The findings suggest that SPHK1 could be a potential biomarker and therapeutic target for CRC, with implications for the development of targeted therapies to improve patient outcomes.
Authors
- Rui Ma (ORCID: https://orcid.org/0000-0003-4607-7604)
- Si-Xiang Lin
- Qianqian Lu (ORCID: https://orcid.org/0000-0003-3624-8094)
- Zhaonan Zhang (ORCID: https://orcid.org/0000-0001-6936-8709)
- Fan-Yong Qu (ORCID: https://orcid.org/0000-0003-1057-1520)
- Yandong Miao (ORCID: https://orcid.org/0000-0002-1429-8915)
- Denghai Mi (ORCID: https://orcid.org/0000-0002-8643-4496)
- Jian Gan (ORCID: https://orcid.org/0000-0003-2645-6076)
- Wuxia Quan (ORCID: https://orcid.org/0000-0002-1898-850X)
- Wen-Yu Luan
- Jiangtao Wang (ORCID: https://orcid.org/0000-0002-1222-164X)
- Shuang Han
- Zhengchao Zhang (ORCID: https://orcid.org/0000-0003-3291-2947)
- Wenhua Huang (ORCID: https://orcid.org/0009-0006-0504-3642)
- Lei Yu (ORCID: https://orcid.org/0000-0002-0237-8758)
- Yan-Jing Ni
- Huimin Wang (ORCID: https://orcid.org/0009-0000-4062-561X)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Online Technologies (United States) (US)
- Xinhui People's Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Southern Medical University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1097/js9.0000000000002506
- Citations
- 3
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.42