Advancing gender-responsive cancer control: A mixed methods evaluation of the leadership program for women in oncology.

9033 Background: Women constitute nearly 70% of the global health and social workforce but hold only 25% of senior leadership roles. Increasing women's representation in leadership is essential to addressing global health challenges and delivering equitable solutions. Leadership programs for women in healthcare enhance skills, confidence, and career progression. The Leadership Program for Women in Oncology (LPWO), developed by City Cancer Challenge (C/Can) in partnership with the American Society of Clinical Oncology (ASCO), aims to empower mid-career women oncologists in C/Can cities to lead transformative cancer care improvements. Combining in-person and virtual training, networking, and mentorship, the LPWO's first cohort was evaluated to assess its impact on participants, institutions, and communities. Methods: Data were collected through surveys and key informant interviews (KIIs) with the 10 program participants from diverse geographic and professional backgrounds. Surveys, conducted at five time points, assessed knowledge across 11 leadership domains. Descriptive and inferential statistical analyses were used to evaluate changes over time. Results: Significant improvements were observed across all leadership domains, with mean scores increasing (p<0.05). KIIs revealed broader impacts, including strengthened team dynamics, strategic institutional involvement, and community engagement. Participants emphasized mentorship and coaching as a cornerstone of the program, fostering professional growth, project development, and connections with global experts. Conclusions: The LPWO demonstrates the potential of targeted leadership programs to drive systemic change. By equipping women oncologists with essential leadership skills, it enables them to advance institutional practices and reduce health disparities. Furthermore, the LPWO plays a critical role in fostering gender-responsive health systems by empowering women leaders to advocate for equitable and inclusive cancer care. Continued investment in similar initiatives, paired with rigorous evaluation, is critical for achieving sustainable global health outcomes.