Synthesis of Ethynyl Trifluoromethyl Sulfide and Its Application to the Synthesis of CF3S-Containing Triazoles
The unprecedented use of ethynyl trifluoromethyl sulfide (CF<sub>3</sub>S-C≡CH) as a synthetically useful building block has been described for the first time. It was reacted with various aromatic and aliphatic azides under copper-catalyzed conditions to yield a novel class of 1,4-disubstituted triazoles bearing the SCF<sub>3</sub> group (15 examples, up to 86% yield).
Authors
- Hussein Hammoudeh
- Floris P. J. T. Rutjes (ORCID: https://orcid.org/0000-0003-1538-3852)
- Daniel Blanco‐Ania (ORCID: https://orcid.org/0000-0001-7605-5559)
- Alejandra Riesco‐Domínguez
Institutions
- Radboud University Nijmegen (NL)
Publication Details
- Journal
- Molecules
- Published
- 2025-05-28
- DOI
- https://doi.org/10.3390/molecules30112358
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission