Computational and biological modeling of IGF1R inhibition for multifocal medulloblastoma
This study offers insights from patient-specific in silico trials for the precision delivery of small-molecule drugs for the treatment of central nervous system (CNS) malignancies.
Authors
- Charles Keller (ORCID: https://orcid.org/0000-0003-2505-7487)
- Bryn A. Martin (ORCID: https://orcid.org/0000-0003-1234-7880)
- Matthew N. Svalina (ORCID: https://orcid.org/0000-0001-9919-9053)
- Sonja Chen (ORCID: https://orcid.org/0000-0001-6174-8723)
- Samuel Cheshier (ORCID: https://orcid.org/0000-0003-4983-6610)
- Bonnie Cole (ORCID: https://orcid.org/0000-0002-3471-1949)
- Dina Kats
- Mohammad Reza Khani (ORCID: https://orcid.org/0000-0001-7753-1780)
- Noah Berlow (ORCID: https://orcid.org/0000-0001-8666-3152)
- Samuel Rasmussen
- Alyssa Almer
Institutions
- Seattle Children's Hospital (US)
- Nationwide Children's Hospital (US)
- Primary Children's Hospital (US)
- University of Idaho (US)
- Huntsman Cancer Institute (US)
- Children's Cancer Therapy Development Institute (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1038/s43856-025-00925-4
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00