Epidemiology of breast cancer and problems of screening.

e13897 Background: Breast cancer is the leading cancer pathology among the female population in terms of incidence and mortality in Uzbekistan. Breast cancer outcomes are driven by a complex interplay of biological factors which impact tumor aggressiveness, in combination with other considerations including access to screening and treatment, treatment adherence, socioeconomic status, and comorbidities. These factors can influence Breast cancer presentations with earlier age at onset, advanced stage at presentation, more aggressive histologies, and may ultimately lead to increased mortality at earlier ages. Methods: The statistical informations taken from the book of “Condition of oncological assistance to the population of the Republic Uzbekistan in 2023”. Results: For highly qualified reading of mammograms based on the Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology has established a reading center, to which mammograms for the 2nd and 3rd expert readings received from regional mammography rooms are sent. To encourage women to undergo mammography screening, commercials and audio recordings were launched on local television and radio. During the installation of the equipment, engineers and specialists conducted training courses on the operation of the equipment and work in the information system for medical personnel (x-ray technicians). To implement the pilot project, the information system “screening.mammo.uz” is used, which is a modern technology that allows for continuous monitoring at each stage of screening, a high level of evaluation of mammographic images, operational management and resolution of organizational issues. Moreover, women can sign up for a screening study on their own through the call center (short number - 1303), however, the majority of women are invited by doctors of family clinics. In 2023, 83,576 women took part in mammographic screening throughout the republic, of which 660 (0.8%) were diagnosed with a malignant neoplasm of the mammary gland, of which 80.8% were diagnosed at the initial stage I-II . Conclusions: Analysis of the results of screening mammography with determination of indications for biopsy of microcalcifications depending on the form of their accumulation made it possible to reduce the number of unjustified biopsies and surgical interventions for diagnostic purposes.