Impact of SGLT2i on Cardiac Remodeling and the Soleus Muscle of Infarcted Rats
Empagliflozin attenuates infarction-induced cardiac remodeling in rats. In soleus muscle, empagliflozin preserves cell trophism, reduces oxidative stress, normalizes muscle and mitochondrial metabolism, and positively modulates proteins involved in synthesis and degradation-related pathways.
Authors
- Bruna B. Brandão (ORCID: https://orcid.org/0000-0001-8762-6310)
- Luana Urbano Pagan (ORCID: https://orcid.org/0000-0003-1865-0207)
- Mariana Gatto (ORCID: https://orcid.org/0000-0002-3115-0795)
- E A Rodrigues (ORCID: https://orcid.org/0000-0002-8592-9374)
- Katashi Okoshi (ORCID: https://orcid.org/0000-0001-8980-8839)
- Paula S. Azevedo (ORCID: https://orcid.org/0000-0002-5843-6232)
- Paula Felippe Martinez (ORCID: https://orcid.org/0000-0001-9477-3386)
- L M Souza (ORCID: https://orcid.org/0000-0002-9726-3901)
- Inês Falcão‐Pires (ORCID: https://orcid.org/0000-0003-1937-3782)
- Leonardo Antônio Mamede Zornoff (ORCID: https://orcid.org/0000-0002-9831-8820)
- Gilson Masahiro Murata (ORCID: https://orcid.org/0000-0003-3383-5410)
- Marina Politi Okoshi (ORCID: https://orcid.org/0000-0001-7728-4505)
- Rodrigo Aparecido Silva
- Albert Santos
- F C Damatto
Institutions
- Universidade Federal de Mato Grosso do Sul (BR)
- Joslin Diabetes Center (US)
- Harvard University (US)
- Universidade de São Paulo (BR)
- Universidade do Porto (PT)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Antioxidants
- Published
- 2025-05-28
- DOI
- https://doi.org/10.3390/antiox14060647
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Estadual Paulista