GANNET53 Part II: A European Phase I/II Trial of the HSP90 Inhibitor Ganetespib in High-Grade Platinum-Resistant Ovarian Cancer—A Study of the GANNET53 Consortium
Although no major safety findings were observed, G + P did not lead to survival benefit. Our companion diagnostic program confirmed that G + P do not favorably cooperate in killing ovarian cancer cells.
Authors
- Jalid Sehouli (ORCID: https://orcid.org/0000-0002-5963-6623)
- Hanno Ulmer (ORCID: https://orcid.org/0000-0001-5911-1002)
- Matthias Dobbelstein (ORCID: https://orcid.org/0000-0001-5052-3967)
- Wolfgang Schmitt (ORCID: https://orcid.org/0000-0002-7870-138X)
- Florence Joly (ORCID: https://orcid.org/0000-0001-7004-9895)
- Nicole Concin
- Ulrich Canzler (ORCID: https://orcid.org/0000-0002-0148-3193)
- Ute M. Moll (ORCID: https://orcid.org/0000-0003-1908-7516)
- Christian Marth (ORCID: https://orcid.org/0000-0002-8965-9981)
- Eva Obermayr (ORCID: https://orcid.org/0000-0001-6324-2961)
- Atanas Ignatov (ORCID: https://orcid.org/0000-0002-9006-4029)
- Sven Mahner (ORCID: https://orcid.org/0000-0002-0640-129X)
- Pierre Combe (ORCID: https://orcid.org/0000-0002-7321-7345)
- Ignace Vergote (ORCID: https://orcid.org/0000-0002-7589-8981)
- Alain G. Zeimet (ORCID: https://orcid.org/0000-0001-5306-2334)
- Elena Ioana Braicu (ORCID: https://orcid.org/0000-0001-5357-6001)
- Daniela Kramer
- Regina Berger (ORCID: https://orcid.org/0000-0003-2952-6797)
- Frédèric Selle (ORCID: https://orcid.org/0000-0002-7016-5383)
- Nicole Heinzl
- Adriaan Vanderstichele (ORCID: https://orcid.org/0000-0002-3984-2948)
- Éric Pujade-Lauraine (ORCID: https://orcid.org/0000-0002-0759-7263)
- Robert Zeillinger (ORCID: https://orcid.org/0000-0001-6771-4591)
- Isabelle Laure Ray-Coquard (ORCID: https://orcid.org/0000-0003-2472-8306)
- Philipp Harter (ORCID: https://orcid.org/0000-0002-9663-5005)
- Els Van Nieuwenhuysen (ORCID: https://orcid.org/0000-0001-5432-1828)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Innsbruck Medical University (AT)
- Universität Hamburg (DE)
- Universität Innsbruck (AT)
- Johannes Gutenberg University Mainz (DE)
- LMU Klinikum (DE)
- Humboldt-Universität zu Berlin (DE)
- Stony Brook School (US)
- Comprehensive Cancer Center Vienna (AT)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Centre Léon Bérard (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- National Center for Tumor Diseases (DE)
- Groupe Hospitalier Diaconesses Croix Saint-Simon (FR)
- Universitätsmedizin Göttingen (DE)
- Centre François Baclesse (FR)
- Arcagy Gineco (FR)
- University Hospital Magdeburg (DE)
- AZ Delta (BE)
- Kliniken Essen-Mitte (DE)
- University Hospital Carl Gustav Carus (DE)
- Freie Universität Berlin (DE)
- Medical University of Vienna (AT)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Stanford University (US)
- Université de Caen Normandie (FR)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3705
- Citations
- 2
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Carol M. Baldwin Breast Cancer Research Fund
- European Commission
- National Cancer Institute