Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway
The achieved outcomes elucidate that CAFs can deliver piR-35462 containing exosomes to OSCC cells and promote OSCC progression via FTO/Twist mediated EMT pathways, and could represent a promising therapeutic target for OSCC.
Authors
- Hanyu Ma
- Shaohai Chang (ORCID: https://orcid.org/0000-0002-7820-3006)
- Ruixin Wang (ORCID: https://orcid.org/0000-0002-4395-8492)
- Yushan Ye (ORCID: https://orcid.org/0000-0003-3307-8712)
- Yongmei Tan
- Jinsong Li (ORCID: https://orcid.org/0000-0001-6833-5390)
- Bowen Li (ORCID: https://orcid.org/0000-0001-8475-4800)
- Fan Wu (ORCID: https://orcid.org/0000-0001-7763-8852)
- Min Fu (ORCID: https://orcid.org/0000-0001-6524-9833)
- Tianjun Lan (ORCID: https://orcid.org/0000-0002-5680-6164)
- Siqi Ren (ORCID: https://orcid.org/0000-0002-1734-6230)
- Yu Peng
- Lianxi Mai
- Xiaodi Feng
- Xiao Tan
- Shule Xie
Institutions
- Sun Yat-sen University (CN)
- Shantou University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1186/s12903-025-06082-3
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Chinese Society of Clinical Oncology