Synthesis of 5‐Arylselenyluracils via Bromide‐Catalyzed Selective C( <i> sp <sup>2</sup> </i> )‐H Selenylation of Uracils
Abstract Herein, an efficient method for the synthesis of 5‐arylselenyluracils via bromide‐catalyzed selective C( sp 2 )‐H selenylation of uracils using boronic acid and elemental selenium as the selenyl source was successfully developed. This method proceeded smoothly for a series of arylboronic acids and uracils under metal‐free and strong oxidant‐free conditions. This protocol offered simple catalytic conditions, high efficiency, good functional group compatibility, easy operation, and easy scalable. Furthermore, the mechanistic studies suggested that this transformation was possibly undergone via a radical pathway.
Authors
- Feng Zhao (ORCID: https://orcid.org/0000-0001-5810-744X)
- Jinhui Cai (ORCID: https://orcid.org/0000-0002-7624-5499)
- Huaixin Wei (ORCID: https://orcid.org/0000-0003-2372-9155)
- Mingming Yu (ORCID: https://orcid.org/0009-0007-4705-7548)
- Zhouting Zeng
Institutions
- Zhejiang Sci-Tech University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Suzhou University of Science and Technology (CN)
- University of South China (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1002/ajoc.202500415
- Citations
- 12
- Primary Topic
- Organoselenium and organotellurium chemistry
- Type
- article
- Field-Weighted Citation Impact
- 15.69
Funders
- National Natural Science Foundation of China