Regional and demographic trends in mortality from breast cancer and cerebrovascular diseases in United States from 1999-2019: A retrospective analysis.

e13776 Background: Breast cancer and cerebrovascular diseases significantly contribute to mortality in the United States, with disparities observed across gender, ethnicity, and geography. This study analyses mortality trends to identify high-risk populations and inform targeted public health interventions. Methods: Mortality data were extracted from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research (CDC WONDER) database from 1999 to 2020. Age-adjusted mortality rate (AAMR) and Crude Mortality Rate (CMR) per 100,000 individuals and annual percent changes (APC) with 95% Confidence Intervals (CI) were calculated. Results: Between 1999 and 2020, 42,418 deaths related to breast cancer and cerebrovascular diseases were reported in the United States. The AAMR declined from 0.8 to 0.6 but rose significantly from 2016 to 2020 (APC: 7.01, 95% CI: -1.01 to 15.70). Females consistently had higher AAMR than males, with values of 1.3 vs. 0.1 in 1999 and 1.0 vs. 0.1 in 2020. Although female AAMR dropped overall, it increased notably from 2018 to 2020 (APC: 11.73, 95% CI: -0.19 to 25.09). African Americans had higher AAMR (1.0 to 0.8) than Whites (0.8 to 0.5), though both groups saw increases from 2016 to 2020: APC 7.46 (95% CI: -0.63 to 16.12) and APC 4.94 (95% CI: 0.12 to 10.00), respectively. Conclusions: Between 1999 and 2020, breast cancer and cerebrovascular-related mortality rates generally showed a decline in AAMR, with notable increases in certain groups, including females, African Americans, and urban populations in recent years. These trends underscore the need for targeted public health efforts and interventions, particularly in high-risk populations and regions experiencing rising mortality rates.