Methylation risk score of C-reactive protein associates sleep health with related health outcomes
C-reactive protein (CRP) reflects inflammation status and is linked to poor sleep, metabolic and cardiovascular health. Methylation (MRS) and polygenic risk scores (PRS) reflect long-term systemic inflammation, and genetically-determined CRP, respectively. To refine understanding of inflammation-linked sleep and health outcomes, we construct PRS-CRPs using GWAS summary statistics and a previously-developed MRS-CRP in the Hispanic Community Health Study/Study of Latinos. Via survey-weighted linear regression, we estimate associations between blood-, PRS-, and MRS-CRP, with multiple sleep and health outcomes (n = 2217). MRS-CRP and PRS-CRPs are associated with increasing blood-CRP level by 43% and 23% per standard deviation. MRS-CRP is associated with obstructive sleep apnea (OSA) traits, long sleep duration, diabetes and hypertension, while PRS-CRPs were not. Blood-CRP level is associated with sleep duration and diabetes. Adjusting for MRS-CRP weakens OSA-diabetes/hypertension associations. Consequently, MRS-CRP is a stronger marker than blood-CRP and PRS-CRP to systemic inflammation associated with poor sleep and related comorbidities.
Authors
- Brian Spitzer
- Danielle A Wallace
- Tamar Sofer (ORCID: https://orcid.org/0000-0001-8520-8860)
- Carmen R. Isasi (ORCID: https://orcid.org/0000-0003-2700-9593)
- Jerome I. Rotter (ORCID: https://orcid.org/0000-0001-7191-1723)
- Sonya Kaur (ORCID: https://orcid.org/0000-0003-4962-6066)
- Susan Redline (ORCID: https://orcid.org/0000-0002-6585-1610)
- Alberto R. Ramos (ORCID: https://orcid.org/0000-0002-9861-6609)
- Stephen S. Rich (ORCID: https://orcid.org/0000-0003-3872-7793)
- Héctor M. González (ORCID: https://orcid.org/0000-0001-8711-2627)
- Martha L. Daviglus (ORCID: https://orcid.org/0000-0002-6791-8727)
- Myriam Fornage (ORCID: https://orcid.org/0000-0003-0677-8158)
- Ziqing Wang (ORCID: https://orcid.org/0009-0000-4702-4681)
- Kent D. Taylor
- Lifang Hou (ORCID: https://orcid.org/0000-0001-7058-4281)
- Peter Y. Liu (ORCID: https://orcid.org/0000-0003-2439-0915)
- Tianyi Huang
- Jon Peter Durda (ORCID: https://orcid.org/0009-0008-1630-4240)
Institutions
- University of Vermont (US)
- Northwestern University (US)
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University of Miami (US)
- Emory University (US)
- UCLA Medical Center (US)
- University of California San Diego (US)
- Cancer Research And Biostatistics (US)
- Brown Foundation (US)
- National Institute on Aging (US)
- Harbor–UCLA Medical Center (US)
- University of Virginia (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Communications Biology
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1038/s42003-025-08226-1
- Citations
- 2
- Primary Topic
- Obesity, Physical Activity, Diet
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Office of Dietary Supplements
- University of Miami
- Northwestern University
- San Diego State University
- National Institutes of Health
- University of Illinois at Urbana-Champaign
- Gillings School of Public Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute on Deafness and Other Communication Disorders
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute on Minority Health and Health Disparities