Cobalt-Catalyzed Cascade Synthesis of 5-Amino-1,2,4-triazolo[1,5-<i>c</i>]quinazoline Derivatives via Multiple C–N Bonds Construction
A cobalt-catalyzed three-component cascade reaction for the synthesis of functionalized 5-amino-1,2,4-triazolo[1,5-<i>c</i>]quinazoline derivatives is presented. The reaction involves <i>ortho</i>-cyanoaryl isocyanides, azides, and hydrazides, giving products in good to excellent yields. The protocol is highly scalable, as demonstrated by a gram-scale reaction of bioactive CGS-15943, providing a robust, efficient method for synthesizing triazoloquinazoline derivatives and offering significant potential for drug discovery and further modifications.
Authors
- Xiaoping Xu (ORCID: https://orcid.org/0000-0001-8031-3688)
- You Zi (ORCID: https://orcid.org/0000-0002-6960-2646)
- Sifan Wu (ORCID: https://orcid.org/0000-0003-2534-8874)
- Shun‐Jun Ji (ORCID: https://orcid.org/0000-0002-4299-3528)
- Zhengkun Li (ORCID: https://orcid.org/0000-0001-9724-3057)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Laboratoire de Synthèse Organique (FR)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1021/acs.joc.5c00658
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions