Mortality trends in metabolic syndrome and colorectal, endometrial, and breast cancers in the US (1999–2020).

e13582 Background: Metabolic syndrome (MS) increases the risk of colorectal, endometrial, and breast cancers, contributing to significant mortality. This study examines U.S. mortality trends (1999–2020), focusing on demographic and regional disparities. Methods: CDC WONDER data for adults 25+ from 1999 to 2020 were analyzed. Age-adjusted mortality rates (AAMRs) per million were calculated by gender, race/ethnicity, age, and region. Trends were assessed using Joinpoint regression, with average annual percentage change (AAPC), 95% confidence intervals (CIs), and p-values. Results: MS-related cancers caused 231,437 deaths, with AAMRs per million rising from 27.91 in 1999 to 57.7 in 2020 (AAPC: 2.86% p < 0.000001). Gender: Females had higher mortality (175,568 deaths; AAMR: 61.93) than males (55,869 deaths; AAMR: 28.53) with AAPCs of 3.08% ( p < 0.000001) for females and 2.78% (p < 0.000001) for males. Age: Elderly (65+) had significantly higher AAMRs (215.77/million) than adults 25–64 (7.72/million). Elderly AAMRs peaked in 2020 at 245. Adults 25–64 saw the highest AAMR in 2020 at 12.2/million. AAPCs: 4.71% ( p < 0.000001) for adults and 2.53% (p < 0.000001) for the elderly. Race: Blacks had the highest AAMR (79.45), while Hispanics had the steepest increase (AAPC: 4.78% p < 0.000001). AAMRs also rose for Whites (46.53), American Indians (42.02), and Asians (29.58). Geography: The South had the highest mortality (81,463 deaths; AAMR: 53.38) and the steepest increase (AAPC: 4.38%; p < 0.000001). The Midwest followed (AAMR: 53.38), while the Northeast had the lowest (46.04). Conclusions: Mortality from MS-related cancers rose significantly from 1999 to 2020, with disparities. Targeted interventions are needed for at-risk populations, especially females, elderly, Blacks, and residents of the South. Strengthened public health efforts focusing on prevention and MS management may help reduce this growing burden. Cohort Age Adjusted Mortality Rate per Million Population Average Annual Percentage Change 95% Confidence Interval P value 1999 - 2020 Overall 48.38 2.8592* 2.1147 to 3.6735 < 0.000001 Males 28.53 2.7795* 1.8762 to 3.64 < 0.000001 Females 61.93 3.0819* 2.3888 to 3.9544 < 0.000001 NH American Indian or Alaska Native 42.02 5.6027* 3.393 to 9.9472 < 0.0004 NH Asian or Pacific Islander 29.58 1.6086* 0.6695 to 2.9628 < 0.005599 NH Black or African American 79.45 2.2152* 1.2057 to 3.4581 < 0.000001 NH White 49.25 2.9279* 2.2345 to 3.6027 < 0.000001 Hispanic or Latino 34.91 4.7843* 4.0465 to 5.9487 < 0.000001 Northeast 46.04 1.8320* 1.1087 to 2.5619 < 0.000001 Midwest 53.38 1.8160* 0.9502 to 2.6767 < 0.000001 South 47.14 4.3780* 3.6056 to 5.0992 < 0.000001 West 47.07 2.7548* 2.1277 to 3.5761 < 0.000001 Urban 46.73 2.6724* 1.9499 to 3.471 < 0.000001 Rural 56.31 3.6542* 2.8122 to 4.8041 < 0.000001