Comparative efficacy of preventive vs. therapeutic resveratrol in modulating gut microbiota and alleviating inflammation in DSS-induced colitis
This study redefines preventive RSV as a microbial ecosystem engineer that preemptively fortifies the gut against inflammation via microbiome-immune-metabolic crosstalk. By prioritizing ecological prevention over symptom suppression, our findings offer a transformative "food as medicine" strategy for IBD, highlighting RSV's potential as a chronotherapeutic agent to reshape clinical paradigms.
Authors
- Jie Lei (ORCID: https://orcid.org/0000-0002-3429-4436)
- Bing Yu (ORCID: https://orcid.org/0000-0003-4643-072X)
- Kecong Wei
- Xie Qing-li
- Zongjing Yang (ORCID: https://orcid.org/0009-0008-2919-0326)
- Lanlan Jiang (ORCID: https://orcid.org/0000-0002-2666-9883)
- Wei Luo (ORCID: https://orcid.org/0000-0002-4317-636X)
- Yuanyuan Fan (ORCID: https://orcid.org/0000-0002-2307-063X)
- Shouming Qin (ORCID: https://orcid.org/0000-0002-7411-0101)
- Luo Yaping
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- BMC Immunology
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1186/s12865-025-00718-3
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- National Natural Science Foundation of China