The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability
These findings support the inhibition of distant vascular permeability for the prevention of tumor metastasis and unveil the anti-vascular permeability factor VIAN-c4551 as a potential and safe therapeutic drug able to prevent metastasis generation by lowering the extravasation of melanoma cells.
Authors
- Carmen Clapp (ORCID: https://orcid.org/0000-0002-7670-6718)
- Daniela Granados-Carrasco
- Gonzalo Martı́nez de la Escalera (ORCID: https://orcid.org/0000-0002-4309-3476)
- Elva Adán‐Castro (ORCID: https://orcid.org/0009-0003-6911-0515)
- Magdalena Zamora (ORCID: https://orcid.org/0000-0001-5579-1004)
- Jakob Triebel (ORCID: https://orcid.org/0000-0002-1989-8645)
- Juan Pablo Robles (ORCID: https://orcid.org/0000-0001-8429-1914)
- Thomas Bertsch
- Alma Lorena Perez
- Manuel M. Bahena
- Regina M. Aramburo-Williams
Institutions
- Rapt Therapeutics (United States) (US)
- Nuremberg Hospital (DE)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1371/journal.pone.0316983
- Citations
- 1
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Consejo Nacional de Ciencia y Tecnología
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México