SGLT2is Versus Metformin for Delirium Prevention in Type 2 Diabetes: A Real-World, Head- to-Head Comparative Study
This first head-to-head, real-world study suggests that SGLT2is may offer superior protection against delirium compared with metformin in patients with T2D, especially in high-risk populations. These findings support the inclusion of cognitive outcomes in diabetes treatment decisions and suggest a potential shift in first-line therapy strategies.
Authors
- Szu‐Yuan Wu (ORCID: https://orcid.org/0000-0001-5637-558X)
- Mengrong Miao (ORCID: https://orcid.org/0000-0002-6956-8599)
- Shuang Lv
- Zhongyuan Lu (ORCID: https://orcid.org/0000-0002-0897-7006)
- Wan‐Ming Chen (ORCID: https://orcid.org/0009-0009-6628-0635)
- Yi Yang (ORCID: https://orcid.org/0000-0002-9400-1850)
- Xiaoling Wang
- Jianqiang Zhang (ORCID: https://orcid.org/0000-0002-9331-4601)
- Mingyang Sun (ORCID: https://orcid.org/0000-0003-3181-6793)
Institutions
- Fu Jen Catholic University (TW)
- Asia University (TW)
- Luodong Poh-Ai Hospital (TW)
- Zhengzhou University (CN)
- Henan Academy of Sciences (CN)
- Henan Provincial People's Hospital (CN)
- Wan Fang Hospital (TW)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-05-28
- DOI
- https://doi.org/10.2337/dc25-0433
- Citations
- 2
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China