Glioblastoma-enriched glycosphingolipids modulate the function of human iNKT cells
The modulation of iNKT cell functions by GSC-enriched glycosphingolipids may contribute to the immunosuppression of GBM and highlights sulfatide production as a potential therapeutic target for GBM treatment.
Authors
- Jinkyu Jung (ORCID: https://orcid.org/0000-0002-8359-6246)
- Alexander Y. Mitrophanov (ORCID: https://orcid.org/0000-0002-9019-4034)
- Vibhuti Joshi (ORCID: https://orcid.org/0000-0003-4102-1775)
- John C. Hancock (ORCID: https://orcid.org/0000-0002-7747-7814)
- Md Masud Alam
- Guzal Khayrullina (ORCID: https://orcid.org/0000-0002-9130-4274)
- Mioara Larion (ORCID: https://orcid.org/0000-0002-7016-9587)
- Orieta Celiku (ORCID: https://orcid.org/0000-0002-0500-1032)
- Emily E Steffke (ORCID: https://orcid.org/0000-0003-3350-9818)
- Byram H. Ozer
- Mark R. Gilbert (ORCID: https://orcid.org/0000-0003-2556-9722)
- Tyrone Dowdy (ORCID: https://orcid.org/0000-0002-6833-8089)
- Jenny E. Gumperz (ORCID: https://orcid.org/0000-0003-1852-2192)
- Hye Kyung Kim (ORCID: https://orcid.org/0009-0005-4043-4406)
- Masaki Terabe (ORCID: https://orcid.org/0000-0002-1777-0189)
- Ayaka Hara
- M. M. Coombs
- Seketoulie Keretsu
- Nargis Malik (ORCID: https://orcid.org/0000-0003-1294-1660)
- Helena Muley Vilamú
- Laila Latifi
- Jo Spurgeon
Institutions
- National Institutes of Health (US)
- University of Wisconsin–Madison (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1093/neuonc/noaf135
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00