Hypothalamic regulated physiological function and gene expression changes suggest high fructose corn syrup intake affects neurodevelopment in adolescent female rats
Among the different caloric-sweetened solutions, young female rats drinking HFCS solution showed food selectivity, elevated basal stress, and reproductive irregularity, which are characteristics associated with ASD. RNA-Seq revealed DEGs in rats drinking HFCS solution, included disrupted circadian sleep cycles, neurotoxicity, and ASD. The results of this preclinical study suggest that HFCS intake should be limited due to its potential for increasing the risk of neurodevelopmental disorders.
Authors
- Sundus S. Lateef (ORCID: https://orcid.org/0000-0001-6913-833X)
- Joseph C. Gigliotti (ORCID: https://orcid.org/0000-0003-4507-4727)
- Eloisa Vendemiatti (ORCID: https://orcid.org/0000-0003-4920-7582)
- Vanessa L. Mueller
- Janet C. Tou (ORCID: https://orcid.org/0000-0002-1874-9111)
- R. Chris Skinner (ORCID: https://orcid.org/0000-0003-1777-7644)
- Vagner A. Benedito (ORCID: https://orcid.org/0000-0002-2131-7651)
Institutions
- University of Vermont (US)
- West Virginia University (US)
- West Virginia University Hospitals (US)
- Liberty University (US)
Publication Details
- Journal
- Nutritional Neuroscience
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1080/1028415x.2025.2509751
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00