Knockdown of PARM1 Alleviates Aortic Valve Calcification via the PRKCH-MAPK Signaling Pathway
With the aging of the population, the prevalence of calcific aortic valve disease (CAVD) has increased yearly. However, effective means to delay or even reverse the progression of CAVD are still lacking. This study revealed that prostate androgen-regulated mucin-like protein 1 (PARM1) expression was significantly up-regulated in calcified aortic valve tissues. Functional investigations demonstrated that PARM1 knockdown effectively suppressed osteogenic differentiation of valvular interstitial cells (VICs) and mitigated pathological aortic valve calcification. Mechanically, PARM1 knockdown down-regulated PRKCH mRNA expression, consequently attenuating MAPK pathway activation during the osteogenic differentiation of VICs. In conclusion, PARM1 could be a feasible target for CAVD prevention.
Authors
- Jin Lu (ORCID: https://orcid.org/0000-0002-0946-3357)
- Naifang Cao (ORCID: https://orcid.org/0009-0000-9315-0822)
- Shuangshuang Yang (ORCID: https://orcid.org/0000-0003-0871-6356)
- Haochang Hu (ORCID: https://orcid.org/0000-0003-3798-1773)
- Jinyong Chen (ORCID: https://orcid.org/0009-0003-9807-2458)
- Xianbao Liu (ORCID: https://orcid.org/0000-0003-1556-9198)
- Dao Zhou (ORCID: https://orcid.org/0000-0001-7815-9490)
- Ningjing Qian (ORCID: https://orcid.org/0000-0002-8707-2757)
- Junhui Xue
- Si Cheng (ORCID: https://orcid.org/0000-0001-7788-4850)
- Hanyi Dai (ORCID: https://orcid.org/0000-0002-7782-891X)
- Juan Fang (ORCID: https://orcid.org/0000-0002-0207-3436)
- Jianan Wang (ORCID: https://orcid.org/0000-0002-4583-3204)
- Lan Xie (ORCID: https://orcid.org/0000-0001-5831-8730)
- Xian Zhu
- Wei Zhu (ORCID: https://orcid.org/0000-0001-7721-7193)
- Yi Qian (ORCID: https://orcid.org/0000-0001-8054-6887)
- Dilin Xu
- Wangxing Hu (ORCID: https://orcid.org/0000-0002-7065-4822)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1016/j.jacbts.2025.02.019
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00