An in-vitro study of the timing between protamine sulfate administration and cardiotomy suction termination

This investigation demonstrated an analysis of heparin reversal via protamine administration. The findings revealed that in the majority of samples, the PTD was sufficient to decrease the ACT below 480 s, the determined benchmark upon which CPB can be safely conducted. After 1/3 of the full protamine dose was given, nearly every sample's ACT reached a value considered unsafe for bypass. The interpretation of the data suggests that there are significant grounds for advocating for a more disciplined approach to cardiotomy suction termination to preserve the integrity of the CPB circuit and to safely conduct CPB.