Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany
This study provides first insights into the distribution of C. difficile genotypes, corresponding antimicrobial resistance, and clonal relatedness using cgMLST, highlighting RT027 as the second most common genotype for the studied area. For the monomorphic RT027 and RT078 populations, new definitions of clonal relatedness might be necessary.
Authors
- Fabian K. Berger (ORCID: https://orcid.org/0000-0002-9081-597X)
- Esther E. Dirks (ORCID: https://orcid.org/0009-0005-6946-1723)
- Johannes Elias (ORCID: https://orcid.org/0000-0002-5878-7040)
- Alexander Mellmann (ORCID: https://orcid.org/0000-0002-0649-5185)
- Goran Söhl
- Inna Friesen (ORCID: https://orcid.org/0000-0002-1374-6974)
- Ralf Ignatius (ORCID: https://orcid.org/0000-0001-9020-8312)
- Vanessa Pfiffer (ORCID: https://orcid.org/0000-0001-9252-8344)
- Johannes Friesen (ORCID: https://orcid.org/0000-0002-8632-2988)
- Mardjan Arvand (ORCID: https://orcid.org/0000-0002-7664-5150)
Institutions
- Robert Koch Institute (DE)
- University of Applied Sciences Potsdam (DE)
- University Hospital Münster (DE)
- Vivantes Klinikum (DE)
- Medizinisches Versorgungszentrum Prof. Mathey, Prof. Schofer (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- Center for HIV and Hepatogastroenterology (DE)
- DRK Kliniken Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Saarland University (DE)
Publication Details
- Journal
- Antimicrobial Resistance and Infection Control
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1186/s13756-025-01565-y
- Citations
- 1
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Bundesministerium für Gesundheit
- Robert Koch Institut