Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors
Abstract This study assesses newly synthesized chromones with a 3,4‐dihydropyrimidin‐2(1H)‐one core at C‐3, combined with triazole derivatives for their antidiabetic potential. Compounds 5a and 5b showed strong inhibition of α‐glucosidase, with IC 50 values of 58.99 ± 4.15 nmol and 49.18 ± 2.18 nmol. Docking studies indicated effective binding within the active site of α‐glucosidase (−10.7 kcal/mol for 5a and −10.9 kcal/mol for 5b). Computational assessments suggested both compounds have favorable profiles for drug‐likeness, ADME, and toxicity, highlighting their potential as therapeutic agents for diabetes.
Authors
- Naresh Kumar Katari (ORCID: https://orcid.org/0000-0002-5737-8528)
- Satyanarayana Yatam (ORCID: https://orcid.org/0000-0002-5212-4588)
- Bhumireddy Chinnachennaiahgari Venkatesh (ORCID: https://orcid.org/0000-0003-3115-4654)
- T. B. Patrudu
- Kumara Swamy Taviti
- Rambabu Gundla (ORCID: https://orcid.org/0000-0002-6469-6022)
- Vishnuvardhana Kishore Polisetti
Institutions
- Acharya Nagarjuna University (IN)
- Lamar State College–Port Arthur (US)
- Varsha Bioscience and Technology (India) (IN)
- GITAM University (IN)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-05-28
- DOI
- https://doi.org/10.1002/slct.202405463
- Citations
- 1
- Primary Topic
- Synthesis of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.39