Compatibility Studies of Minoxidil with Different Excipients by Using DSC, TGA and FTIR

This study aims to understand the compatibility or incompatibility of minoxidil with these excipients, which are commonly included in drug formulations for various purposes. The study examined the interaction of minoxidil with several excipients including mannitol, calcium phosphate dibasic, butylated hydroxyanisole, magnesium stearate, cellulose, Beta-cyclodextrin, Eudragit S 100, sodium carboxymethyl cellulose, and talc. Morphological and thermal properties were analyzed using techniques such as DSC, TGA, and FTIR. Minoxidil was found to be compatible with Beta-cyclodextrin, calcium phosphate dibasic, cellulose, and sodium carboxymethyl cellulose. This suggests that these excipients can be used in formulations with minoxidil without causing any adverse interactions. However, minoxidil was found to be incompatible with Eudragit S 100, mannitol, magnesium stearate, and talc. This indicates that these excipients may not be suitable for use in formulations with minoxidil due to potential interactions that could affect stability, safety, efficacy, or quality of the drug dosage form. These findings provide valuable insights for formulators and researchers in the pharmaceutical industry to develop stable and effective formulations containing minoxidil. It underscores the importance of understanding the interactions between active pharmaceutical ingredients and excipients to ensure the quality and performance of drug products.