Sphingosine kinase 1 facilitates gastric cancer progression via STAT1 gene methylation-mediated mechanisms
This study clarified the mechanism by which <i>SPHK1</i> affects the development of GC through regulating the methylation of the <i>STAT1</i> gene and provides a certain theoretical basis for the clinical exploration of novel methods for treating GC.
Authors
- Jiabei Xie (ORCID: https://orcid.org/0000-0003-0312-1433)
- Yunfei Wang (ORCID: https://orcid.org/0000-0001-7555-5308)
- Fei Wang (ORCID: https://orcid.org/0000-0002-1122-5286)
- Lijie Yuan (ORCID: https://orcid.org/0000-0002-3662-7433)
- Shuangyin Han (ORCID: https://orcid.org/0000-0002-2914-6340)
- Jia Lu (ORCID: https://orcid.org/0000-0002-2877-6826)
- Bingxi Zhou
Institutions
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.21037/tcr-2025-948
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00