Voxel-Based Morphometric Analysis of the Mini-Mental State Examination and the Mini-Mental State Examination-2 in Patients With Mild Cognitive Impairment and Alzheimer’s Disease in Korea

The MMSE-2 demonstrated broader and stronger associations with cortical gray matter volume compared to the K-MMSE. In particular, MMSE-2:EV emerged as a more effective cognitive screening tool in clinical settings due to its widespread correlations across key brain regions, including the frontal lobe-a region inadequately assessed by the K-MMSE. These findings highlight the enhanced sensitivity of MMSE-2 in detecting structural brain changes associated with cognitive decline.