Electroencephalographic microstate evidence of visual network hyperactivation in children with autism spectrum disorder

Abstract Visual hypersensitivity, including extreme visual sensitivity and avoidance response, is one of the main features of autism spectrum disorder (ASD). It has been proposed to be an effect of aberrant sensory integration and impaired functional brain networks. EEG microstates reflect brain activity fluctuations and offer an innovative way to study the neurological framework of visual hypersensitivity in ASD. The study included 54 children aged 6–9 years: 27 with ASD and 27 typically developing (TD) peers matched for age and gender. 64‐channel EEG data were recorded while the subjects were at rest with their eyes open. The duration, occurrence, and coverage of Microstate B were substantially higher in children with ASD than in the TD group (all p < 0.05), suggesting increased stability and activation of the visual network and impaired cross‐network resource allocation. ASD participants showed increased transitions from D to B ( p = 0.003) and A to B ( p = 0.022), indicating more frequent switching to the visual network and excessive visual attention allocation, which maybe the potential neural mechanism of visual hypersensitivity in ASD children. These results indicate disrupted functional network dynamics and increased visual network dominance in ASD, offering insights into the neurological basis of visual hypersensitivity.