Exosomes derived from fibroblasts enhance skin wound angiogenesis by regulating HIF-1α/VEGF/VEGFR pathway
Overall, we demonstrate central roles for exosomal miR-24-3p in stimulating endothelial HIF-VEGF signaling by inhibiting VHL-mediated degradation. The findings establish fibroblast-derived exosomes as promising acellular therapeutic candidates to treat vascular insufficiency underlying recalcitrant wounds.
Authors
- Han‐Ming Shen (ORCID: https://orcid.org/0000-0001-7369-5227)
- Guang Xiu Lu (ORCID: https://orcid.org/0000-0002-2268-1033)
- Jiacai Yang (ORCID: https://orcid.org/0000-0002-3543-9238)
- Gaoxing Luo
- Wengang Hu (ORCID: https://orcid.org/0000-0002-3843-650X)
- Yong Huang (ORCID: https://orcid.org/0000-0003-4939-3493)
- Zhihui Liu (ORCID: https://orcid.org/0000-0001-7136-8150)
- Yunxia Chen (ORCID: https://orcid.org/0000-0002-2653-3927)
- Weifeng He (ORCID: https://orcid.org/0000-0002-5302-4669)
- Cheng Chen (ORCID: https://orcid.org/0000-0002-4331-1074)
- Jue Wang (ORCID: https://orcid.org/0000-0001-7503-1133)
- Xiaorong Zhang (ORCID: https://orcid.org/0000-0003-0277-5574)
- Xiaohong Hu (ORCID: https://orcid.org/0000-0002-7196-737X)
- Ruoyu Shang (ORCID: https://orcid.org/0000-0001-5353-9702)
- Jun Hu (ORCID: https://orcid.org/0000-0002-7013-0703)
- Wenjing Yin (ORCID: https://orcid.org/0009-0009-2613-633X)
Institutions
- Army Medical University (CN)
- Sun Yat-sen University (CN)
- National University of Singapore (SG)
- University of Macau (MO)
- Southwest Hospital (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/burnst/tkae071
- Citations
- 15
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 12.09
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China