Lactate trains immunity
Understanding the mechanisms implicated in the establishment of trained immunity could aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin (BCG) vaccination in a human cohort, Ziogas and colleagues demonstrate the role of lactate generation and its use for histone lactylation as a key mechanism for establishing innate immune memory.
Authors
- Claudio Mauro (ORCID: https://orcid.org/0000-0002-3736-0099)
- Alba Llibre
Institutions
- University of Birmingham (GB)
Publication Details
- Journal
- Trends in Immunology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.it.2025.05.002
- Citations
- 2
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Bill and Melinda Gates Foundation
- British Heart Foundation
- Medical Research Council