Leptin and inflammatory pathways in the Alzheimer's disease continuum: Implications for glial activation and neuropsychiatric symptoms
These findings underscore the relevance of exploring how leptin and adipose tissue dysfunction interact with neuroinflammatory processes in contributing to NPS in the patients in the AD continuum. Interventions targeting these interactions could represent promising avenues for managing NPS.
Authors
- Yoshie Omachi
- Takeshi Ikeuchi (ORCID: https://orcid.org/0000-0001-8828-8085)
- Akinori Takeda (ORCID: https://orcid.org/0000-0002-8673-8772)
- Yasuyuki Kimura (ORCID: https://orcid.org/0000-0002-7927-9483)
- Nobuyoshi Shimoda (ORCID: https://orcid.org/0000-0003-0321-8905)
- Aya Ogata (ORCID: https://orcid.org/0000-0002-6474-6229)
- Fumihiko Yasuno (ORCID: https://orcid.org/0000-0002-5981-5795)
- Kengo Ito (ORCID: https://orcid.org/0000-0002-5700-688X)
- Kensaku Kasuga (ORCID: https://orcid.org/0000-0002-2178-0769)
- Takashi Kato (ORCID: https://orcid.org/0000-0002-0571-0883)
- Saori Hattori
- Kastunori Yokoi
- Takashi Sakurai (ORCID: https://orcid.org/0000-0002-2369-3095)
- Hiroshi Ikenuma
- Takashi Nihashi (ORCID: https://orcid.org/0000-0002-5544-7649)
- Kazuyuki Nakagome (ORCID: https://orcid.org/0000-0003-3138-1451)
- Junichiro Abe
- Hiroyuki Minami
Institutions
- Gifu University of Medical Science (JP)
- National Center of Neurology and Psychiatry (JP)
- National Center for Geriatrics and Gerontology (JP)
- Niigata University (JP)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.bbih.2025.101018
- Citations
- 3
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 2.74
Funders
- Japan Agency for Medical Research and Development
- Japan Health Research Promotion Bureau
- National Center for Geriatrics and Gerontology
- Japan Society for the Promotion of Science