Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship
16S ONT sequencing showed higher sensitivity and diagnostic yield than CSF culture, providing clinical insights for managing CNS infections through targeted antibiotic use and enhanced antimicrobial stewardship in resource-limited settings.
Authors
- Vu Viet Sang
- Nguyen Thi Khanh Linh
- Peter G. Kremsner (ORCID: https://orcid.org/0000-0002-3926-4113)
- Lê Hữu Song (ORCID: https://orcid.org/0000-0003-2056-8499)
- Do Van Dong (ORCID: https://orcid.org/0009-0001-7325-1674)
- Dennis Nurjadi (ORCID: https://orcid.org/0000-0002-1278-5939)
- Tran Thi Lien
- Thirumalaisamy P. Velavan (ORCID: https://orcid.org/0000-0002-9809-9883)
- Le Thi Kieu Linh
- Van Dinh Trang
- Nguyen Thi Ngoc Nga (ORCID: https://orcid.org/0009-0006-0679-6742)
- Trần Thị Huyền (ORCID: https://orcid.org/0000-0002-9794-5718)
- Nghiêm Xuân Hoàn (ORCID: https://orcid.org/0000-0002-6426-7818)
- Hoàng Xuân Quang
Institutions
- Duy Tan University (VN)
- Military Hospital (PK)
- Hai phong University Of Medicine and Pharmacy (VN)
- Hai Phong University (VN)
- Universitätsklinikum Tübingen (DE)
- Centre de Recherche Médicales de Lambaréné (GA)
- University Hospital Schleswig-Holstein (DE)
- German Center for Infection Research (DE)
- Vietnam Military Medical University (VN)
- Hai Phong University of Management and Technology (VN)
- Vietnamese - German Center of Excellence in Medical Research (VN)
- Hospital for Tropical Diseases (VN)
- 108 Military Central Hospital (VN)
- University of Lübeck (DE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1093/infdis/jiaf280
- Citations
- 5
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 5.92
Funders
- Deutscher Akademischer Austauschdienst
- Eberhard Karls Universität Tübingen