Long-term exposure to constant light disrupts intestinal stem cells through sympathoexcitation-induced Wnt5a signaling inhibition
Taken together, these data indicate that sympathoexcitation is critical for disruption of ISC under constant light exposure, suggesting that targeting β1-adrenoceptor/oxidative stress/<i>Wnt5a</i> axis may be a potential strategy for ISC disruption induced by prolonged sustained light exposure, providing a new direction for IBS treatment.
Authors
- Weizhong Wang (ORCID: https://orcid.org/0000-0001-6979-4505)
- Xing Haw Marvin Tan
- Qin-Yao Li
- Jia‐Cen Sun (ORCID: https://orcid.org/0000-0003-1060-1531)
- Lingfeng Liu (ORCID: https://orcid.org/0000-0002-0298-0191)
- Yu-Wan Wang (ORCID: https://orcid.org/0009-0004-2739-4625)
- Huasheng Wang (ORCID: https://orcid.org/0000-0001-9530-6587)
Institutions
- Shanghai University (CN)
- Naval Medical Research Command (US)
- Shanghai University of Engineering Science (CN)
- Southwest Medical University (CN)
Publication Details
- Journal
- Gastroenterology report
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gastro/goaf031
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation