Polygenic scores for dizygotic twinning: insights into the genetic architecture of female fertility
Female fertility appears to exists on a genetic spectrum, with anovulation/infertility at one end and DZT at the other. Results suggest that the DZT PGS can be of added value to evaluate female fertility and be incorporated in clinical practice in the future.
Authors
- Nicholas G. Martin (ORCID: https://orcid.org/0000-0003-4069-8020)
- Nikki Hubers (ORCID: https://orcid.org/0000-0001-6030-9235)
- René Pool (ORCID: https://orcid.org/0000-0001-5579-0933)
- Cornelis B. Lambalk
- Jouke‐Jan Hottenga (ORCID: https://orcid.org/0000-0002-5668-2368)
- Erik A. Ehli (ORCID: https://orcid.org/0000-0002-7865-3015)
- Gonneke Willemsen (ORCID: https://orcid.org/0000-0003-3755-0236)
- Jeffrey J. Beck (ORCID: https://orcid.org/0000-0002-1152-9968)
- Hamdi Mbarek (ORCID: https://orcid.org/0000-0002-1108-0371)
- Siri E. Håberg (ORCID: https://orcid.org/0000-0002-2199-5225)
- Christian M. Page (ORCID: https://orcid.org/0000-0002-1897-3666)
- Jenny van Dongen (ORCID: https://orcid.org/0000-0003-2063-8741)
- Dorret Irene Boomsma (ORCID: https://orcid.org/0000-0002-7099-7972)
- Elizabeth C. Corfield (ORCID: https://orcid.org/0000-0002-0119-157X)
- Lannie Ligthart (ORCID: https://orcid.org/0000-0002-6570-3319)
- Velja Mijatovic (ORCID: https://orcid.org/0000-0002-0435-9921)
- Jennifer R. Harris
Institutions
- Norwegian Institute of Public Health (NO)
- QIMR Berghofer Medical Research Institute (AU)
- Lovisenberg Diakonale Høgskole (NO)
- Lovisenberg Diakonale Sykehus (NO)
- Avera McKennan Hospital & University Health Center (US)
- Cognitive Research (United States) (US)
- University of Bergen (NO)
- Vrije Universiteit Amsterdam (NL)
- Inholland University of Applied Sciences (NL)
- Qatar Foundation (QA)
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1007/s10815-025-03515-4
- Primary Topic
- Assisted Reproductive Technology and Twin Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stiftelsen Kristian Gerhard Jebsen
- Trond Mohn stiftelse
- Koninklijke Nederlandse Akademie van Wetenschappen
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Helse- og Omsorgsdepartementet
- Novo Nordisk
- Universitetet i Bergen
- Norges Forskningsråd
- Norwegian Institute of Public Health
- National Institute of Mental Health
- H2020 European Research Council