Predicting progression from MCI to dementia using cortical disarray measurement from diffusion MRI
Cortical minicolumn-related diffusivity metrics measure neurodegeneration. We compare the predictive value of magnetic resonance imaging (MRI) measures for mild cognitive impairment to dementia progression. Microstructural cortical disarray outperforms macrostructural markers. These results support using diffusion MRI biomarkers to identify and monitor at-risk patients.
Authors
- Pegah Khosropanah (ORCID: https://orcid.org/0000-0002-5255-7631)
- Mario Torso (ORCID: https://orcid.org/0000-0002-5284-9167)
- Gerard R. Ridgway (ORCID: https://orcid.org/0000-0002-7676-7860)
- Steven A. Chance (ORCID: https://orcid.org/0000-0001-6060-3805)
Institutions
- Oxford Medical Diagnostics (United Kingdom) (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70310
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00