Alterations of Myocardial Ketone Metabolism in Heart Failure with Preserved Ejection Fraction (HFpEF)
In HFpEF mice, the heart switches from glucose oxidation to fatty acid oxidation, with ketone oxidation being impaired. Increasing ketone supply to the heart via ketone ester supplementation or SGLT2 inhibitor treatment increases myocardial ketone oxidation rates but was not associated with functional improvements. Unlike HFrEF, ketone supplementation strategies may be less effective in HFpEF due to an impairment of myocardial ketone oxidation in HFpEF.
Authors
- John M. Seubert (ORCID: https://orcid.org/0000-0003-0764-3933)
- Ezra B. Ketema (ORCID: https://orcid.org/0000-0001-6546-0591)
- Cory S. Wagg
- Gary D. Lopaschuk (ORCID: https://orcid.org/0000-0003-1010-0454)
- Liye Fang (ORCID: https://orcid.org/0000-0001-7566-7916)
- Nathan Wong (ORCID: https://orcid.org/0000-0001-7715-8592)
- Liyan Zhang (ORCID: https://orcid.org/0000-0003-4582-2414)
- Kaleigh Wei
- Qiuyu Sun
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1002/ehf2.15319
- Citations
- 4
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 5.55