<scp>SFXN1</scp> Reduction Alleviates Cerebral Ischemia–Reperfusion Injury by Promoting Neuronal Survival and Reducing Neuroinflammation
This study reveals the novel role of SFXN1 in exacerbating cerebral I/R injury by reducing neuronal survival through the modulation of mitochondrial function and promotion of microglia-mediated neuroinflammation via NF-κB activation.
Authors
- Xin Zhou (ORCID: https://orcid.org/0000-0002-6942-4800)
- Mengfei Lv
- Jing Xu (ORCID: https://orcid.org/0000-0002-0940-738X)
- Zhaolong Zhang (ORCID: https://orcid.org/0000-0003-3145-9730)
- Xiangyu Xu (ORCID: https://orcid.org/0000-0002-2485-4671)
- Zhongying Duan (ORCID: https://orcid.org/0009-0000-2809-4609)
- Qi Wan (ORCID: https://orcid.org/0000-0001-6014-1620)
- Yu Cui (ORCID: https://orcid.org/0000-0002-3480-0730)
- Rui Zhao (ORCID: https://orcid.org/0000-0002-8267-0336)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shenzhen University Health Science Center (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1111/cns.70457
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Natural Science Foundation of China
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China