Symptom networks in major depressive disorder and treatment response: special focus on TRD
Treatment reduced global network strength across outcome groups. However, distinct symptom networks were found in patients showing response to treatment, non-response, and TRD. More easily targetable symptoms such as reduced-appetite were central to networks in patients with response, while pessimistic thoughts may be a key symptom upholding disease burden in TRD.
Authors
- Stuart Montgomery (ORCID: https://orcid.org/0000-0002-5983-0063)
- Joseph Zohar (ORCID: https://orcid.org/0000-0002-6925-9104)
- Alexander Kautzky (ORCID: https://orcid.org/0000-0001-9251-8285)
- Julien Mendlewicz (ORCID: https://orcid.org/0000-0002-6131-2732)
- Chiara Fabbri (ORCID: https://orcid.org/0000-0003-0276-7865)
- Dan Rujescu (ORCID: https://orcid.org/0000-0002-1432-313X)
- Siegfried Kasper (ORCID: https://orcid.org/0000-0001-8278-191X)
- Lucie Bartova (ORCID: https://orcid.org/0000-0002-1769-8025)
- Markus Dold (ORCID: https://orcid.org/0000-0001-8914-2192)
- Daniel Souery (ORCID: https://orcid.org/0000-0003-3434-5958)
- Alessandro Serretti (ORCID: https://orcid.org/0000-0003-4363-3759)
- Tibor Harkany (ORCID: https://orcid.org/0000-0002-6637-5900)
- Evgenii O. Tretiakov
Institutions
- University of London (GB)
- Université Libre de Bruxelles (BE)
- Università degli Studi di Enna Kore (IT)
- Sheba Medical Center (IL)
- Comprehensive Cancer Center Vienna (AT)
- AFA Insurance (Sweden) (SE)
- Universidad de Londres (MX)
- Imperial College London (GB)
- Medical University of Vienna (AT)
- National Agency for Social Insurance (SE)
- University of Bologna (IT)
Publication Details
- Journal
- European Psychiatry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1192/j.eurpsy.2025.2454
- Citations
- 1
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- University of Cambridge
- H. Lundbeck A/S