Advancements in Biomarkers for Early Detection and Risk Stratification of Cardiovascular Diseases—A Literature Review
The advancement of cardiovascular biomarkers has significantly enhanced early detection, risk stratification, and personalized treatment. Emerging biomarkers, including genetic variants, metabolomics, microRNAs, and imaging-based markers, provide deeper insights into disease mechanisms. Integrating multi-omic approaches with artificial intelligence may further refine predictive accuracy and therapeutic decision-making. However, clinical translation requires rigorous validation through large-scale, multicenter studies to ensure reliability and applicability across diverse populations. Standardization, cost-effectiveness assessments, and the development of biomarker panels are essential for clinical adoption. Future research should focus on bridging discovery and implementation, advancing precision medicine to improve cardiovascular outcomes.
Authors
- Abubakar Nazir (ORCID: https://orcid.org/0000-0002-6650-6982)
- Safi ur Rehman Sadiq
- Syed Zawahir Hassan (ORCID: https://orcid.org/0000-0002-7116-1114)
- Muhammad Shah Wali Jamal
- Usama Afzaal (ORCID: https://orcid.org/0000-0002-5322-0889)
- Awais Nazir (ORCID: https://orcid.org/0000-0001-8440-4667)
- Ozo Akah
- Shafaq Aman
Institutions
- Houston Methodist (US)
- King Edward Medical University (PK)
- Rwanda Meteorological Service (RW)
- St John of God Hospital (AU)
Publication Details
- Journal
- Health Science Reports
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/hsr2.70878
- Citations
- 16
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 26.69