Dual roles of IRE1α inhibition in reversing mitochondrial ROS-induced CD8<sup>+</sup> T-cell senescence and exerting direct antitumor effects in multiple myeloma
Inhibiting IRE1α represents a promising strategy to reverse the senescence of CD8<sup>+</sup> T cells by mitigating mtROS production. This dual mechanism not only rejuvenates T cells but also directly targets myeloma cells, offering a novel therapeutic approach for MM treatment.
Authors
- Mengping Chen (ORCID: https://orcid.org/0000-0002-5709-4824)
- Honghui Huang (ORCID: https://orcid.org/0000-0002-6748-8798)
- Jian Hou (ORCID: https://orcid.org/0000-0002-2813-5850)
- Fajun Nan (ORCID: https://orcid.org/0000-0002-2284-3637)
- Yike Wan (ORCID: https://orcid.org/0000-0003-1199-5755)
- Zhiqiang Liu (ORCID: https://orcid.org/0000-0002-0677-8097)
- Jingjing Wang (ORCID: https://orcid.org/0009-0003-5543-878X)
- Junying Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shandong Tumor Hospital (CN)
- National Center for Drug Screening (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/jitc-2024-011044
- Citations
- 8
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 14.16
Funders
- National Natural Science Foundation of China