The Association between CK, CK-MB, and Osteoporotic Fracture Patients

Objective: To investigate the association between creatine kinase (CK), creatine kinase myocardial band (CK-MB), and osteoporotic fracture. Methods: The clinical data of 60 patients with osteoporotic fractures and 52 patients with normal physical examinations were analyzed retrospectively. The above individuals were set as an osteoporotic fracture group and a control group. Age, body mass index, serum C-reactive protein, CK and CK-MB between the two groups were compared. Analyses of the relationship between biochemical indexes and osteoporotic fractures were employed by Pearson correlation analysis, receiver operating characteristic curve (ROC) and multiple logistic regression model. Results: A higher level of age was found in the osteoporotic fracture group than in the control group, and lower levels of serum CK and CK-MB of the osteoporotic fracture group than in the control group were observed (P < 0.05, respectively). The age of the osteoporotic fracture group was significantly negatively correlated with CK and CK-MB (P < 0.05). After age adjustment, the CK and CK-MB were protective factors for osteoporotic fractures (P < 0.05). Conclusion: Lower levels of serum CK and CK-MB were found in osteoporotic fracture patients and were adversely linked with age. The serum CK and CK-MB may be new diagnostic indicators of osteoporotic fracture.