Genetic origin of multifocal sporadic medullary thyroid cancer and C-cell hyperplasia
Our data demonstrate that multiple foci of sMTC share the same driver mutation as the main tumor and support the hypothesis that they are intrathyroidal metastases. Most of the CCH associated with sMTC should not be considered a preneoplastic lesion as they are negative for the mutation of the main sMTC.
Authors
- Beatrice Fuochi
- Cristina Romei (ORCID: https://orcid.org/0000-0002-5957-8902)
- Clara Ugolini (ORCID: https://orcid.org/0000-0002-3489-8280)
- Raffaele Ciampi (ORCID: https://orcid.org/0000-0001-6345-9343)
- Roberta Casalini (ORCID: https://orcid.org/0009-0001-6017-5166)
- Rossella Elisei (ORCID: https://orcid.org/0000-0002-5333-9257)
- Francesca Signorini (ORCID: https://orcid.org/0000-0003-3769-8783)
- Virginia Cappagli (ORCID: https://orcid.org/0000-0003-0726-8125)
- Jacqueline Fátima Martins de Almeida (ORCID: https://orcid.org/0000-0003-0811-7652)
- Laura Sterian Ward (ORCID: https://orcid.org/0000-0003-1601-3220)
- Teresa Ramone
Institutions
- University of Pisa (IT)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1093/ejendo/lvaf109
- Citations
- 1
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Conselho Nacional de Desenvolvimento Científico e Tecnológico