Development of a four autophagy-related gene signature for active tuberculosis diagnosis
Our findings yielded a four-gene signature in whole blood that is robustly diagnostic for ATB, validated across multiple evaluation datasets and clinical samples. The autophagy-driven specificity and PCR-compatible design of this signature offer a blood-based, cost-effective strategy to enhance TB detection, addressing WHO-aligned diagnostic needs.
Authors
- Zhenqiong Liu
- Qixun Fang
- Renhui Huang
- Kevin Lin (ORCID: https://orcid.org/0000-0002-1236-9847)
- Jia Feng (ORCID: https://orcid.org/0000-0003-2132-2503)
- Xingan Xing (ORCID: https://orcid.org/0000-0002-5248-4153)
- Jingping Xu
- Baoyan Ren
Institutions
- Bioscience Research (US)
- Jiangxi Chest Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-23
- DOI
- https://doi.org/10.3389/fcimb.2025.1600348
- Citations
- 4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.58