Synthesis and Antimicrobial Activity of Novel Sulfonyl Piperidine Carboxamide Derivatives Prepared from N-Boc-Piperidine-3-carboxylic Acid via Amide Coupling

Piperidines serve as pivotal synthetic building blocks in the realm of drug design, with their derivatives forming essential parts of a wide range of drugs and alkaloids. This study presents a novel approach involving sulfonyl derivatives of piperidine-3-carboxylic acid, achieved through amide coupling with substituted sulphonyl chlorides. The synthesized compounds underwent characterization via IR, 1H NMR, 13C NMR and MS analyses. Specifically, a series of novel sulphonamides derived from 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid was synthesized, given the significance of sulphonamides as a vital drug class. Antimicrobial activity screening against both Gram-positive and Gram-negative bacteria, as well as fungi, was evaluated. The MIC concentration results revealed moderate to good activity against Gram-positive and Gram-negative microorganisms and fungal organisms.