Demonstration of an enhanced dosing pattern for debulking large and bulky unresectable tumors via differential hole‐size spatially fractionated radiotherapy

All differential hole-size SFRT replans were clinically acceptable, with C = 3 cm, S = 2 cm, and P = 1.5 cm providing the optimal setting for select tumors. Differential lattice patterns enhanced the ablative dose to the bulky tumors while restricting the maximum dose to adjacent critical organs.