Endoscopic Dilation for Fibrostenotic Complications in Eosinophilic Esophagitis—A Narrative Review

Esophageal fibrotic remodeling is a major complication of chronic inflammation in eosinophilic esophagitis (EoE) and represents one of the main determinants of symptoms in adult patients with EoE, with a remarkable impact on patients’ quality of life and the healthcare system. Esophageal fibrotic remodeling is diagnosed through upper gastrointestinal endoscopy, radiological studies, and a functional luminal imaging probe. However, diagnostic underestimation of esophageal strictures and suboptimal adherence to EoE guidelines still represent limitations of current clinical practice. Combined with medical therapy and/or elimination diets, endoscopic dilation remains the cornerstone treatment for esophageal strictures and rings, offering a safe and effective option for managing obstructive symptoms. Different modalities are available for esophageal endoscopic dilation of EoE, including mechanical and balloon dilators. Mechanical dilators provide tactile feedback during the procedure and exert longitudinal and radial forces. In contrast, balloon dilators apply a purely radial force and enable direct visualization of the esophageal mucosa during the procedure. Both mechanical and balloon dilators are safe and effective, with no single modality demonstrating clear superiority. Consequently, the choice of dilation technique is guided by stricture characteristics, the expertise of the endoscopist, and considerations related to the financial and environmental sustainability of the devices. This review aims to summarize the most relevant evidence on the endoscopic evaluation and dilation of fibrostenotic complications in EoE, also providing practical guidance for clinicians to optimize the endoscopic management of these patients.

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Publication Details

Journal
Allergies
Published
2025-05-26
DOI
https://doi.org/10.3390/allergies5020017
Primary Topic
Eosinophilic Esophagitis
Type
article
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article

Endoscopic Dilation for Fibrostenotic Complications in Eosinophilic Esophagitis—A Narrative Review

Roberto Penagini, David James Tate, Marco Michelon, Andrea Sorge et al.
1 links
Allergies
Eosinophilic Esophagitis
article

Endoscopic Dilation for Fibrostenotic Complications in Eosinophilic Esophagitis—A Narrative Review

Roberto Penagini, David James Tate, Marco Michelon, Andrea Sorge, Michele Montori, Marina Coletta, Edoardo Vincenzo Savarino, Pieter Jan Poortmans, Maria Eva Argenziano, Pierfrancesco Visaggi
article en

Abstract

Esophageal fibrotic remodeling is a major complication of chronic inflammation in eosinophilic esophagitis (EoE) and represents one of the main determinants of symptoms in adult patients with EoE, with a remarkable impact on patients’ quality of life and the healthcare system. Esophageal fibrotic remodeling is diagnosed through upper gastrointestinal endoscopy, radiological studies, and a functional luminal imaging probe. However, diagnostic underestimation of esophageal strictures and suboptimal adherence to EoE guidelines still represent limitations of current clinical practice. Combined with medical therapy and/or elimination diets, endoscopic dilation remains the cornerstone treatment for esophageal strictures and rings, offering a safe and effective option for managing obstructive symptoms. Different modalities are available for esophageal endoscopic dilation of EoE, including mechanical and balloon dilators. Mechanical dilators provide tactile feedback during the procedure and exert longitudinal and radial forces. In contrast, balloon dilators apply a purely radial force and enable direct visualization of the esophageal mucosa during the procedure. Both mechanical and balloon dilators are safe and effective, with no single modality demonstrating clear superiority. Consequently, the choice of dilation technique is guided by stricture characteristics, the expertise of the endoscopist, and considerations related to the financial and environmental sustainability of the devices. This review aims to summarize the most relevant evidence on the endoscopic evaluation and dilation of fibrostenotic complications in EoE, also providing practical guidance for clinicians to optimize the endoscopic management of these patients.

AllergiesVol. 5(2)
University of Pisa (IT), Marche Polytechnic University (IT), University of Padua (IT), University of Milan (IT), Ghent University Hospital (BE), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Ghent University (BE)
Openalex Percentile: Top 79%
Eosinophilic Esophagitis
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